Metro City is the main setting of the film Megamind. Metro City, as suggested by its name, is a large metropolis. After crash-landing on Earth, Metro Man and Megamind both end up in Metro City, Metro Man becoming the hero and defender of the town, with Megamind as his nemesis. Megamind has a habit of incorrectly pronouncing the town's name as "Metrocity" (similar to "atrocity"), something which comes back to bite him when he briefly poses as Metro Man.
The town's mayor is known simply as the Mayor of Metro City. However, in the film Megamind vs. the Doom Syndicate, the reporter Roxanne Ritchi successfully runs for the position of mayor, a role she continues in the series Megamind Rules!
The exact location of the city is unknown but based on where the Death Ray fired at Metro Man in the observatory, it appears to be in Michigan, USA, located near the border of Lake Michigan.